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apalutamide will reduce the extent or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications which are CYP3A4 substrates may lead to reduce exposure to these prescription drugs.Use of this web site is den